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7.2 Metabolic reprogramming First-line antidiabetic agents targeting AMPK and PPAR- exhibit potent immunomodulatory and cytoprotective effects through metabolic pathway modulation

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[] However, it should be mentioned that, in contrast to other trials that showed promising benefits, the NAC dosage and treatment duration in this research were small, and anxiety was not measured as an endpoint

Then, ATP depletion leads to the failure of energy-dependent ion pumps (e.g., Na + /K + -ATPase), resulting in ionic imbalances, including the influx of calcium (Ca 2+ ), sodium (Na + ), and chloride (Cl ) ions into the cell, and the efflux of potassium (K + ) [23]

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