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In summary, omega-3 fatty acids interfere with the normal operation of multiple signaling pathways, including EGFR and PI3K/Akt, by remodeling the lipid composition and microstructure of cell membranes, inhibiting proliferation and survival signals, and enhancing apoptotic signals in tumor cells

HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells

OxPAPCs can further skew the differentiation of Tregs towards Th1 cells via IFN- signaling (Appleton et al

Saturated fatty acids contained in animal fats can induce an inflammatory response, including the expression of proinflammatory transcription factors that induce inflammatory mediators (including cytokines), which affects the development and progression of many chronic diseases [144]

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