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Impairment in the PPI response is a characteristic behavior observed in schizophrenia patients 35,36,37 as well as in NMDAR hypofunction models of SZ 38

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Blocking NNMT preserves the NAD+ precursor pool (1.2-1.6x increase in intracellular NAD+), increases SAM availability for epigenetic methylation, and activates SIRT1/SIRT3 signaling

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