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FIGURE 4 In vitro Release Studies In vitro release of WL from CNF and coumarin fraction was assessed in SNES solution prepared in PBS (pH 7.4) at 37 0.2C for a time period of 24 h

2.2 Cryptococcus Cryptococcosis is a life-threatening invasive fungal infection primarily caused by Cryptococcus neoformans and Cryptococcus gattii , accounting for approximately 152,000 new cases and 110,000 deaths annually, predominantly among immunocompromised individuals such as HIV/AIDS patients and organ transplant recipients (Kwon-Chung et al., 2014)