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Here, Coyle and Paul discuss drugs with promising new mechanisms under development for schizophrenia, including those targeting glutamatergic and cholinergic signalling.
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Furthermore, several sigma-2 receptor ligands are under investigation, including CT1812, rivastigmine and SAS0132
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There is evidence that an imbalance between brain excitation (glutamate) and inhibition (GABA) is one of the driving factors behind migraine attacks
