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Importantly, the predictive value of these studies depends on matching each therapeutic mechanism to models that faithfully capture the relevant pathological bottleneck (for example, inflammation, OPC differentiation, axonal vulnerability or repair failure)

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In the empatic-360 group, 82.6% of patients lost at least 5% of their baseline body weight and 47.7% lost at least 10% of their baseline body weight as compared to 18.9% and 5.7% patients in the placebo group, respectively [192]

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