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The core clinical value of this drug class lies in their use as adjuncts to L-DOPA, significantly prolonging patients' "on" time, shortening "off" time, and potentially reducing the total daily dose of L-DOPA

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In conventional epilepsy treatments, drug resistance to anti-epileptic drugs can occur when drug does not pass the BBB sufficiently, as a result from improper dosing and wrong drug choice [222]