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Decrease dose consideration: Persistent side effects including headaches, fatigue, or injection site reactions, excessive response (extremely rapid weight loss suggesting dose may be higher than needed), cost concerns when lower doses might achieve similar results
Among these components, the IGF axis includes hybrid receptors composed of IGF-1R and INSR isoforms
10.1371/journal.pone.0041339 70 JinY.CaiD.MoL.JingG.ZengL.ChengH.et al (2024)
Mueller ST, Piper BJ
1b, Supplementary Fig
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