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SLE commonly affects multiple systems including mucocutaneous tissues, musculoskeletal system, hematological system, and kidneys, with an estimated global prevalence of 3.4 million cases [1]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 48.Huang T., Zhang K., Sun L., Xue X., Zhang C., Shu Z., Mu N., Gu J., Zhang W., Wang Y., et al

Chemokines : Various chemokines attracting immune cells are secreted, such as IL-8 (CXCL8), GRO/ (CXCL1/2), MCP-1 (CCL2), MCP-2 (CCL8), RANTES (CCL5), MIP-1 (CCL3), and SDF-1 (CXCL12) [57]

Without enough folate, cells can get damaged, and the body may rely more on glucose for energy instead of breaking down proteins and fats

Recent research has revealed that glial cells are not only passive responders but also active modulators of psychiatric and neurodegenerative disorders