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The human evidence is limited, but the mechanistic rationale is enough that this remains an active research area

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Polypodium extract: this natural ingredient is derived from plants & functions as an antioxidant

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The effect of a high-dose vitamin b multivitamin supplement on the relationship between brain metabolism and blood biomarkers of oxidative stress: a randomized control trial

Interestingly, only one case of Reyes syndrome associated with Kawasaki disease has ever been reported, and only in the Japanese literature, giving an incidence of 0.005%