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This observation is also supported by functional MRI (fMRI) studies showing that patients with early-stage mild cognitive impairment (MCI) display an hyperactivation of medial temporal lobe and hippocampal circuits during memory tasks, possibly reflecting inefficient compensatory activity 157,158,159,160,161,162,163 which has also been referred to as excessive and maladaptive synaptic plasticity

BBB disruption also enhances - and -secretase activity, promoting increased A production [157]

[DOI] [PubMed] [Google Scholar] 40.de Oliveira DCX, Rosa FT, Simes-Ambrsio L, Jordao AA, Deminice R

PMID: 42199653 Carbohydr Polym Tech2025 Sep

Heffernan and colleagues treated obese wild-type mice and 3-AR knockout mice with human growth hormone and with AOD-9604, comparing the responses