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Two decades ago, inventor David Schmidt found himself on a mission to solve a critical problem for Navy SEALs
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Compounds with aldehyde functional groups are far more toxic to S
Mechanistically, stabilization of wild-type p53 and induction of the p53 target gene CDKN1A (p21) leads to decreased expression of the ribonucleotide reductase (RNR) subunits RRM1 and RRM2
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