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It also inhibits matrix metalloproteinases (MMPs), enzymes that degrade ECM, preserving skin structure

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Neuropathic pain-relieving drugs are only modestly effective and often do not eliminate pain, leaving a significant unmet need [181,186]

Hambright WS, Fonseca RS, Chen L, Na R, Ran Q (2017) Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

NO and S-Nitrosylation of Proteins Although many of the effects of NO are exerted via the activation of soluble guanylate, NO can also directly modify the sulfhydryl group of cysteine residues in proteins, a process termed S -nitrosylation

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