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Table 1: Inhibition concentrations (IC 50 and IC 20 ) in U87 MG cells treated for 24, 48, and 72 h with 5-fluorouracil, cisplatin, and paclitaxel at nine different doses (obtained by serial dilution from stock concentrations of 1000 M, 200 M, and 500 nM, respectively)

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As mentioned above, the link between TNF- and ROS adds another dimension of complexity to the TNF signaling network, as ROS act on numerous proteins required for the regulation of cellular homeostasis, including proteins that mediate cell proliferation, survival, death, differentiation, DNA repair and metabolism 30