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Preclinical models converge on immuneinflammatory signaling, HPA axis dysregulation and neurotransmitter alterations as recurrent mechanistic pathways (Ravi et al., 2021

The separation was achieved using a C 8 column with a mobile phase consisting of phosphate buffer adjusted to pH 2.5 (mobile phase A) and acetonitrile (mobile phase B), running in a segmented gradient manner at a flow rate of 0.8 mL/min, and UV detection was performed at 280 nm

Limitations A notable limitation of our study was the small sample size, which should be expanded in future research to yield more reliable and generalizable results

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Thus, inhibition of the MVA pathway may lead to ferroptosis, thereby validating the crucial role of GPX4 activity in preventing ferroptosis

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