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The fact that this redox imbalance occurs as a consequence of GSH depletion may explain why several clinical trials have provided no evidence of significant cataract prevention arising from the administration of high dosages of ascorbic acid [13]

The overnight culture was then diluted 1:100 into 1 L of fresh LB medium supplemented with 50 g ml 1 kanamycin and cultured at 37 C, 160 rpm until OD 600 = 0.40.5

Excessive ROS could cause cells to undergo ferroptosis and accompany a series of changes in cell morphology, such as outer membrane rupture, nuclear integrity, reduction of mitochondrial ridges, and membrane condensation ( Recent studies have found that the loss of histone deubiquitinase MYSM1 can induce ferroptosis and affect the function of hematopoietic stem cell, providing a new clinical approach for treating complex blood diseases (Zhao et al., 2023)

10.1016/j.ebiom.2022.104258 66 LvM.CaiY.HouW.PengK.XuK.LuC.et al (2022)

Jarow, J

doi: 10.1074/jbc.M112.437996