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A recent study showed that nearly 1 in 6 patients with cirrhosis have moderately severe to severe depression and nearly half have moderatesevere anxiety (43)

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Materials and Methods Bacterial strains, growth media, and culture conditions Bacterial strains, plasmids, and primers used in this study are shown in Tables S1S4

STERILE INFLAMMATION AND APAP HEPATOTOXICITY The extensive cell necrosis after an APAP overdose leads to release of damage-associated molecular patterns (DAMPs) including mitochondrial DNA, nuclear DNA fragments, high-mobility group box 1 (HMGB1) protein, and many others108110 (Fig
