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Part of what regular users feel is the reversal of withdrawal rather than a gain above their true baseline, so the pure effect is smaller than the trial count suggests

All these grade 3 were resolved or returned to baseline at the end of the AE

Similarly, cytokines including IL-10, IL-33 and interferon- have been studied for their potential to suppress proinflammatory cytokine production and enhance memory 136

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*Correspondence: Ruben Manuel Luciano Colunga Biancatelli [email protected] This article was submitted to Viral Immunology, a section of the journal Frontiers in Immunology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers