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Based on current clinical evidence, the rough ordering from largest to smallest weight-loss effect is: Tirzepatide highest average weight loss Semaglutide significant weight loss Tesamorelin moderate weight loss, primarily through visceral fat reduction AOD-9604 primarily body composition effects MOTS-c primarily metabolic and energy effects rather than pure weight reduction AOD-9604 and MOTS-c are generally not considered replacements for GLP-1 medications in patients seeking substantial weight reduction

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We did not make sex a variable in measures of body weight because we expected strong main effects of sex there which would not be of particular interest but could mask experimental effects if part of an overall ANOVA

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Vitamin B12 status of pregnant Indian women and cognitive function in their 9-year-old children