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doi: 10.1016/j.bbrc.2015.04.119 142 BaiMLuCAnLGaoQXieWMiaoFet al

Streptozotocin stimulates ATP dephosphorylation, which results in the generation of free radicals and superoxides, with the aid of the beta cells' xanthine oxidase

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This supports the concept of a paracrine role of IGF1 in breast cancer (Fig
