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However, that will only happen if fatigue is caused by being B12 deficient before the shots are started

Treating pernicious anemia (vitamin B12 shots or high oral doses of vitamin B12 are usually used in this case)

Sikiric et al., 2016

It is naturally available in animal products, but deficiencies can occur due to dietary restrictions, malabsorption issues, or certain health conditions

Intramuscular injections deliver usable vitamin B12 faster than subcutaneous injections, yet both injections provide a higher percentage and faster absorption rate than tablets or liquid forms