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Catherine Sampson, Sierra Miller, Kehinde Ogunseye, and Erika Main for help with technical aspects of this study, Dr

observed in Nature Medicine , NNMT inhibition in adipose tissue produced favorable body composition changes without negatively impacting muscle mass (Kraus et al., Nature Medicine )

Retatrutide is an investigational GLP-1, GIP, and glucagon triple receptor agonist currently in Phase 3 trials

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Researchers continue investigating how NNMT-related mechanisms may affect obesity, glucose metabolism, and energy expenditure

Chronic Conditions: Individuals with chronic conditions that affect B12 absorption, such as pernicious anemia or gastrointestinal disorders, may need regular injections throughout their lives