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Localized delivery is ideal for targeted effects, while systemic application is better suited for broader exposure across the body

Less common side effects may include fatigue, headaches, dizziness, or injection site reactions

This is especially important, because these proteins interact with DNA helixes through these sites

Sequencing was performed using a HiSeq 2500 (Illumina), with a read length of 300 bp paired-end reads and at least 25,000 tags per sample