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These findings align with preclinical data showing that circadian disruption enhances TNBC tumor growth and impairs the time-dependent efficacy of cisplatin therapy, suggesting that both intact circadian signaling and melatonin rhythms are crucial for optimizing chemotherapeutic outcomes 58
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The intermittent approach uses 5-10 mg of MOTS-c, 2-3 times per week , usually on training days

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Angiogenesis and Nerve Repair Rodent studies have also documented effects on vascular and neural tissues
