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399 PD-1 blockade also in relapsed/refractory B-cell non-Hodgkins lymphoma in a phase I trial of nivolumab showed promising results, including follicular lymphomas (which often show abundant PD-1 expression on intratumoral CD4 + T cells) and diffuse large B-cell lymphoma (variably expressing PD-1 and PD-L1)

330,331 TMAO inhibitors (e.g., ALG-05, which targets tryptophan indole lyase) curb IS production, easing fibrosis, whereas tight junction enhancers (e.g., chitosan oligosaccharide [COS]) activate intestinal CaSR/AMPK pathways, reducing systemic inflammation and oxidative stress in prediabetes, with COS also balancing mTOR-autophagy dynamics in renal cells

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