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Researchers observed that intra-articular administration was associated with changes in cartilage matrix composition and chondrocyte activity markers in the treated joints compared to controls [3]

COMPLEMENTARY MEDICINE PAIN MANAGEMENT QUALITATIVE RESEARCH STATISTICS & RESEARCH METHODS Clinical trials This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made

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doi: 10.1097/CM9.0000000000001474 2 Sarmento-RibeiroABScorilasAGoncalvesACEfferthTTrougakosIP