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As we age, the superficial blood vessels in the skin become visible through the skin, giving a darker appearance

Yue, X., Liu, S.-L., Guo, J.-N., Meng, T.-G., Zhang, X.-R., Li, H.-X., Song, C.-Y., Wang, Z.-B., Schatten, H., Sun, Q.-Y., & Guo, X.-P

Shaking the vial, storing it at room temperature for extended periods, or using non-sterile water for reconstitution can destroy the compound before it's ever used