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Using a more direct mechanism, oroxylin A, an O-methylated flavone isolated from Scutellaria root, was shown to inhibit glycolysis in MDA-MB-231 and MCF7 breast adenocarcinoma cells

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82474240, and 82274547, Co-construction science and technology project of Science and Technology Department of National Administration of Traditional Chinese Medicine and Zhejiang Provincial Administration of Traditional Chinese Medicine under Grant No

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Beyond classical antioxidant signaling, GSH interfaces with additional pathways, including Hippo-Yes1 associated transcriptional regulator (YAP1) signaling to regulate GPX4 and SLC7A11 expression, 159,160 mechanistic target of rapamycin kinase (mTOR) signaling to influence GPX4 protein synthesis through cysteine metabolism, 161 and NF-B signaling to restrain inflammation-associated ROS production 162