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Acknowledgements The author would like to thank Teresa Seefeldt and Jing Guan for proofreading the manuscript

Taken together, these studies indicate that inducing ferroptosis in HSCs may represent a viable strategy for treating and/or preventing liver fibrosis

3.3.1 Mitochondrial fusion and regulatory mechanisms Mitochondrial fusion is a cellular self-repair mechanism that combines healthy mitochondria with damaged or mutated mitochondria to repair the damage or compensate for the mitochondrial dysfunction caused by mutations through complementary effects, thus ensuring normal mitochondrial function and maintaining normal cellular physiological activities (Twig and Shirihai, 2011)

61 As a result, the stem cells in the scaffold released IL-1Ra in a sustained fashion over the course of 28 days in culture

For MMUT to function properly, a third protein, MMAA, is required to protect MMUT against oxidative stress and to reactivate the enzyme [107]

A.BonomiM.SlotboomD
