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Highly compacted biodegradable DNA nanoparticles capable of overcoming the mucus barrier for inhaled lung gene therapy

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Structural changes and antibody enrichment in the lungs are early features of anticitrullinated protein antibodypositive rheumatoid arthritis

Funding The research conducted is supported by US Army Combat Casualty Care Research Program (CCCRP) H_001_2018_WRAIR (FY18-23) and ongoing support CO240012_WRAIR (FY24-26)

In addition to downregulating FASN at the posttranslational level, GSH depletion also decreased the key lipogenic genes at the transcriptional level, most notably Scd1 and Srebf1 (Figure 3, AC)