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These APX forms undergo structural and functional transitions between HMW and LMW forms

Inflammatory markers such as CRP, IL-1, IL-6 and TNF- elevated both in patients with depression and PCOS (120, 121)

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reported that oridonin alleviates early PF caused by lipopolysaccharide by inhibiting the NLRP3 inflammasome, NOX4-dependent oxidative imbalance, impaired autophagy, and EMT (Yang L

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These patients may benefit from combination therapy with liothyronine (T3) alongside levothyroxine (T4), although more targeted research is needed to confirm individualized treatment responses [111,112,113]