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Through increased labeling of BCKA-derived metabolites and increases in levels of BCAA breakdown, such as glutamate, alanine, and 3-hydroxyisobutyric acid, they discovered that tirzepatide treatment stimulated catabolism of BCAAs/BCKAs in BAT

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Moreover, it restored fitness, fur density and renal function in both fast aging Xpd TTD/TTD and naturally aged mice

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At this point, the cell has reached the so-called Hayflick limit