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Although superoxide is generally considered relatively unreactive compared with other radical species, it can react rapidly with some radicals such as NO and with some iron-sulfur clusters in proteins (136)

Acta 110 PodolakR.EnacheE.StoneW.BlackD

, Because TLS are accompanied by high oxidative stress (Figure 2 and Supplemental Figure 4) and active cell proliferation, we analyzed the expression of the cystine/glutamate transporter within TLS

Nature Methods 2 , 751756 (2005)

This becomes noticeable in most people in their 30s and 40s
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