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doi:10.4067/s0034-98872017000700907
Currently, cancer treatment faces three main challenges: limitations of traditional drug development models, inherent flaws of single-target drugs, and the complexity of tumor mechanisms
These reactive compounds interact with amino groups (NH 2 ) in proteins and DNA bases, leading to the formation of adducts that can cause mutations (Yang et al., 2019)
Biosynthesis of diphosphopyridine nucleotide
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This was due to the presence of autoantibodies against folate receptor which blocked the folate binding site
