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The relevant limit used was 0.25 EU/mL

2 Materials and methods 2.1 Protocol and registration This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement (Moher et al., 2009) and the guidelines from the Cochrane Handbook for Systematic Reviews of Interventions (Supplementary Table S1

doi: 10.1016/j.nutres.2020.12.019 57

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Effects of pentadecapeptide BPC 157 on regional serotonin synthesis in the rat brain: -methyl-L-tryptophan autoradiographic measurements