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HEP-1 also activated the PI3K-AKT signaling pathway, increased the expression of endothelial nitric oxide synthase (eNOS), promoted the expression of serum and glucocorticoid-induced kinase (SGK), and enhanced the biosynthesis of epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF), thereby facilitating the repair and healing of gastric mucosal injury (GMI)

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This suggests that chlorogenic lactones might contribute to the increased protective effects against H2O2-induced death of neuron cells (Chu, 2009)

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Diagnosis of HAPH often relies on echocardiography, cardiac catheterization, and other methods to assess pulmonary artery pressure and its impact on cardiac function