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In fact, those additional constituents may completely or partially explain why this phytomelatonin outperformed synthetic melatonin in cellular assays for inflammation (using COX-2 inhibition) and free radical scavenging [34] (see Table 5)

Lab Investig 85:597607

[DOI] [PubMed] [Google Scholar] 193.Goon PK, Lip GY, Boos CJ, Stonelake PS, Blann AD

Effect of caffeine on quadriceps muscle pain during acute cycling exercise in low versus high caffeine consumers

Also, the male KO mice had an increased CYP1A2 (Part of the P450 enzyme family that are responsible for a large part of detoxification), however this wouldnt really explain the differences seen in Figure 2 (side-note: Ok, this last part was extremely geeky and I try to make this as mainstream as possible