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Progressive studies on SLE demonstrated that lymphocytes apoptosis might play an important role in the pathogenesis of disease
Activated by T-cell receptors and co-stimulatory signals, Gpx4 -knockout Treg cells exhibited abnormal accumulation of lipid peroxides and underwent ferroptosis

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Palmieri F (2014) Mitochondrial transporters of the SLC25 family and associated diseases: a review