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Reduced eNOS activity leads to decreased NO production, which is associated with mitochondrial dysfunction

Emerging epigenetic evidencederived predominantly from experimental animal modelssuggests that prolonged or repeated exposure to supraphysiological doses of anabolicandrogenic steroids may induce persistent molecular alterations in the male reproductive system

Steve Schow and James Keck for their insightful comments and Ms

The antiprotozoal drug nitazoxanide improves experimental liver fibrosis in mice

Conversely, in conditions like hepatic steatosis, this finely tuned feedback loop is disrupted, leading to dysregulated hepatic amino acid metabolism 19

This dual effect further reduces microglial glucose demand, enhancing neuronal substrate availability