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This upregulation extends to key antioxidant systems, including glutathione (GSH) and thioredoxin (TRX), which help maintain redox balance and support tumor survival [35]
Early concerns about stem cells potentially becoming cancerous have not been borne out in clinical practice, though long-term data collection continues

These were cells of sod1 and sod2 strains without activity of superoxide dismutases enzymes which scavenge superoxide anion radical from the cytoplasm and mitochondrial matrix, respectively, as well as strains lacking activity of Msn2p and Msn4p, which activate the environmental stress response programme

10.1016/j.tifs.2016.11.019

doi: 10.1016/j.ijbiomac.2020.06.134

Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer's disease models and human brains
