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Among them, the phenolic hydroxyl network is the core pharmacophore that exerts its anti-oxidation, scavenges free radicals, and directly regulates kinase activity ( in vitro experiments ( 2.3 Biological activity Silybin is extracted from the fruits and seeds of milk thistle

PMID 15476449

"A hospital-based study of anti-TPO titer in patients with thyroid disease." Muller Journal of Medical Sciences and Research 4.2 (2013): 74
Ashraf, 2009

When ligands bind to their receptors, they cause JAK phosphorylation, which then stimulates STAT phosphorylation, which subsequently controls the transcription of target genes which produce chemokines and pro-inflammatory cytokines (Villarino et al

References 1.Cheek M., Nic Lughadha E., Kirk P., Lindon H., Carretero J., Looney B., Douglas B., Haelewaters D., Gaya E., Llewellyn T., et al
