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Further, 5-fluorouracil (5-FU), a uracil analog that inhibits TS, also disrupts the folate cycle and DNA synthesis and is used to treat several types of cancers [170]
Plasma concentrations of acetaminophen and its metabolites (glucuronide, sulfate, cysteine, mercapturate, and glutathione) were determined in 293 blood samples
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10.1016/j.healun.2020.03.012 170 SikandanA.ShinomiyaT.NagaharaY
Deoxyribonucleotide Synthesis: NADPH is required by ribonucleotide reductase for the conversion of ribonucleotides to deoxyribonucleotides, a crucial step in DNA synthesis and repair
The human Herpesvirus dUTPases of EBV and HSV-1 may contribute to neurological disorders by altering the integrity of the blood brain barrier and promoting a pro-inflammatory microenvironment
