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Identifying the potential genes in alpha synuclein driving ferroptosis of Parkinsons disease

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r , Distribution of precursor m/zs in the human blood metabolome meta-analysis dataset

doi: 10.1038/s41586-018-0261-5

Moles A, Torres S, Baulies A, Garcia-Ruiz C, Fernandez-Checa JC (2018) Mitochondriallysosomal axis in acetaminophen hepatotoxicity

To this end, the authors performed two independent CRISPR screens in Karpas299 cells, a lymphoma cell line displaying high lipoprotein uptake: one aimed to identify genes required for resistance to ML210-induced ferroptosis, while the other was conducted to uncover genes involved in lipoprotein uptake