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To test these hypotheses, we used quantitative PCR assays to monitor the expression of carefully selected genes 14 , HSP70, encoding heat shock protein 70, an indicator of cell stress 15,16 , tumour protein P53 ( P53 ), a central transcriptional factor activated by stressors such as UV and involved in cell cycle arrest, DNA repair and apoptosis 17,18 and KIN17 ( KIN ), a cell cycle control protein up-regulated by UV 19,20 and constructed linear mixed effect models 14,21

Lab studies have also shown that the nicotine vapor from e-cigarettes enhanced the aggressive behavior of epithelial lung tissue that already contained mutations

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Based upon studies in animals, it is expected that inhibition of CGRP would alleviate some of the mucus phenotypes in allergic asthma [39]

doi: 10.1161/hc4301.098284

Liu G, Vogel SM, Gao X, Javaid K, Hu G, Danilov SM, Malik AB, Minshall RD (2011) Src phosphorylation of endothelial cell surface intercellular adhesion molecule-1 mediates neutrophil adhesion and contributes to the mechanism of lung inflammation
