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Skeletal Muscle 7:17

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2009) reported a 2.8 point change, which did not reach the MCID threshold and was therefore unlikely to reflect a meaningful benefit in motor symptoms for patients

References 1.Panicker N, Kanthasamy A, Kanthasamy AG

doi: 10.1089/thy.2023.0556 199

Even though it may have been a more common phenotype at one point in time, other environmental variables could result in a shift in the percentage distribution year over year
