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Microbial dysbiosis and biofilm formation in chronic wounds When the microbiomes equilibrium is disrupted (dysbiosis), opportunistic and pathogenic bacteria such as P aeruginosa and S

But several critical gaps remain: No Phase 2 or Phase 3 RCT in humans

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Blam O.G., Vaccaro A.R., Vanichkachorn J.S., Minninch J.M., Albert T.J., Hilibrand A.S., Murphey S.A

Phenotypic switching of VSMCs VSMCs normally maintain a contractile phenotype characterized by high expression of contractile proteins, such as -smooth muscle actin (SMA), smooth muscle myosin heavy chain (SM-MHC), and smooth muscle 22 (SM22) [129]

75,76 In another randomized controlled trial that included 180 women with PCOS and 150 without, all of whom had serum 25-OH vitamin D levels below 30 ng/mL, those with PCOS who received 20,000 IU (500 mcg) vitamin D per week experienced an improved LH:FSH 77 ratio versus placebo