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Further, despite their association with chemoresistance 59 , ABCE1 and ABCF1 are unable to transport substrates through membranes, as these molecules are devoid of a transmembrane domain

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For GSTM1 knockdown, HeLa cells were transfected with scrambled or GSTM1 siRNA (Dharmacon Inc., USA) using the Dharmafect-1 transfection reagent according to manufacturer's instructions

Furthermore, the coexpression of MC3R and GHSR1a in the hypothalamic arcuate nucleus suggests that this dimer may play a role in arcuate-mediated feeding behavior (Roselli-Rehfuss et al., 1993

Nephrotoxicity may occur
