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Our recent genome-wide ChIP-Seq global study also found that NRF2 directly regulates genes involved in PPP along with focal adhesion pathways in A549 NSCLC cells.61 The genes associated with the focal adhesion pathway can promote glucose consumption, lipogenesis and glutamine dependence, ultimately leading to the promotion of tumor growth.62 To shed light on the metabolic features of NRF2-activated lung cancers, Saigusa et al

Targeting ROS-dependent pathways for drug development is challenging because of the dual role, complex regulation, and context-dependent activity of ROS

The biochemical functions of ascorbic acid

Research progress on drugs for diabetes based on insulin receptor/insulin receptor substrate

and in vivo, with influenza [78,79,80,81,82]

Effects of Glutathione Supplementation: A Systematic Review and Meta-Analysis
