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Glucagon mediates its metabolic effect through the GcgR, a member of the 7-transmembrane-spanning G protein-coupled receptor superfamily, which is expressed in the liver, kidney, intestinal smooth muscle, brain, adipose tissue, heart, pancreatic cells, and placenta [13]

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A potent and selective p38 inhibitor protects against bone damage in murine collagen-induced arthritis: a comparison with neutralization of mouse TNFalpha

Through metagenomic sequencing and in vitro coculture experiments of peripheral blood mononuclear cells (PBMCs), it was verified that butyrate can selectively expand peripheral blood Tregs in RA patients, inhibit the activation of conventional T cells (Tconvs), downregulate the production of anti-citrullinated peptide antibodies (ACPA), and reduce cartilage and bone tissue damage

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[DOI] [PubMed] [Google Scholar] 212.Tong L