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S., Geier, J

[DOI] [PubMed] [Google Scholar] 36.McAnulty SR, McAnulty LS, Nieman DC

Stahl et al., 2015)

The magnetically triggered release of Ni 2+ ions from MNPVs embedded in alginate hydrogels has been utilized to remotely trigger and spatially control apoptosis in fibroblasts cultured within the hydrogel

While the C-terminal unit (C0362) is secreted and functions as a cysteine protease that disarms the complement system via degrading key complement factors such as C3 and C4, the N-terminal functional unit (N0362) with two Big domains binds to FPR1 and CXCR1/2 receptors with high affinity and blocks neutrophil chemotaxis and activation most likely through competition inhibition, thereby annihilating both the complement system and neutrophils and rendering bacteria protection from these two innate defense mechanisms

Abbreviations and symbols: increase, decrease, NF-kB: Nuclear factor kappa B